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J Int Med Res. 2015 Dec;43(6):809-18. doi: 10.1177/0300060515594194. Epub 2015 Sep 16.

Efficacy of early intravenous bolus oxycodone or fentanyl in emergence from general anaesthesia and postoperative analgesia following laparoscopic cholecystectomy: A randomized trial.

Author information

1
Department of Dental Anaesthesiology, Seoul National University Dental Hospital, Seoul, Republic of Korea.
2
Department of Anaesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Republic of Korea.
3
Department of Anaesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Republic of Korea ylee@amc.seoul.kr.

Abstract

OBJECTIVES:

To compare prospectively the efficacy of early intravenous bolus of oxycodone or fentanyl in providing analgesia at emergence from general anaesthesia following laparoscopic cholecystectomy.

METHODS:

Patients were randomly assigned to receive either 0.08 mg/kg oxycodone (Group O) or 1 µg/kg fentanyl (Group F), 20 min before the end of surgery. Postoperative pain was evaluated using a visual analogue scale (VAS). The time to first postoperative analgesic dose, requirement for analgesia and side-effects were assessed in the postanaesthesia care unit (PACU).

RESULTS:

The VAS scores at 0 min and 30 min and requirement for analgesia were significantly lower in Group O (n = 28) than in Group F (n = 26). The time to first analgesia dose was significantly longer in Group O than Group F. There were no significant between-group differences in the incidence of side-effects.

CONCLUSIONS:

Oxycodone relieves immediate postoperative pain significantly better than fentanyl, and is not associated with an increase in side-effects in patients undergoing laparoscopic cholecystectomy.

KEYWORDS:

Oxycodone; laparoscopic cholecystectomy; postoperative pain

PMID:
26378067
DOI:
10.1177/0300060515594194
[Indexed for MEDLINE]

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