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Pediatr Blood Cancer. 2016 Jan;63(1):11-6. doi: 10.1002/pbc.25752. Epub 2015 Sep 16.

Advances in Pediatric Intravenous Iron Therapy.

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Department of Pediatrics, Pediatric Hematology/Oncology Unit, Democritus University of Thrace Faculty of Medicine and University General District Hospital of Evros, Alexandroupolis, Thrace, Greece.


Iron deficiency anemia (IDA) continues to be very common worldwide. Intravenous (IV) iron is an infrequently used therapeutic option in children with IDA despite numerous studies in adults and several small but notable pediatric studies showing efficacy and safety. Presently, the availability of newer IV iron products allows for replacement of the total iron deficit at a single setting. These products appear safer compared to the high molecular weight iron dextrans of the past. Herein, we review the medical literature and suggest that front line use of IV iron should be strongly considered in diseases associated with IDA in children.


children; ferric carboxymaltose; ferric gluconate; ferumoxytol; iron deficiency anemia; iron sucrose

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