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Pediatr Res. 2016 Jan;79(1-1):3-12. doi: 10.1038/pr.2015.179. Epub 2015 Sep 16.

The role of systemic inflammation linking maternal BMI to neurodevelopment in children.

Author information

1
Department of Health and Life Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands.
2
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.
3
Department of Pediatrics and Mother Infant Research Institute, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts.
4
Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
5
Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
6
Perinatal Epidemiology Unit, Hannover Medical School, Hannover, Germany.

Abstract

Children of obese mothers are at increased risk of developmental adversities. Maternal obesity is linked to an inflammatory in utero environment, which, in turn, is associated with neurodevelopmental impairments in the offspring. This is an integrated mechanism review of animal and human literature related to the hypothesis that maternal obesity causes maternal and fetal inflammation, and that this inflammation adversely affects the neurodevelopment of children. We propose integrative models in which several aspects of inflammation are considered along the causative pathway linking maternal obesity with neurodevelopmental limitations.

PMID:
26375474
PMCID:
PMC4888781
DOI:
10.1038/pr.2015.179
[Indexed for MEDLINE]
Free PMC Article

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