Adhesive Enrichment and Membrane Turnover at the Heart of Cardiopharyngeal Induction

Robert G Kelly

doi:10.1016/j.devcel.2015.08.023

Adhesive Enrichment and Membrane Turnover at the Heart of Cardiopharyngeal Induction

Dev Cell. 2015 Sep 14;34(5):490-2. doi: 10.1016/j.devcel.2015.08.023.

Author

Robert G Kelly¹

Affiliation

¹ Aix-Marseille University, IBDM CNRS UMR 7288, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France. Electronic address: robert.kelly@univ-amu.fr.

PMID: 26374763
DOI: 10.1016/j.devcel.2015.08.023

Abstract

Differential inductive signaling during asymmetric division of progenitor cells specifies the heart lineage in Ciona intestinalis. In this issue of Developmental Cell, Cota and Davidson (2015) show that differential induction is mediated by FGF receptor regionalization, resulting from asymmetric cell-matrix adhesion and reduced mitotic turnover of polarized Caveolin-rich membrane domains.

Publication types

Comment

MeSH terms

Animals
Cell Division / physiology*
Cell Lineage / physiology*
Ciona intestinalis / cytology*
Fibroblast Growth Factors / genetics*
Gene Expression Regulation, Developmental / physiology*
Heart / embryology*
Myocardium / cytology*

Substances

Fibroblast Growth Factors