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J Natl Cancer Inst. 2015 Sep 14;107(11). pii: djv250. doi: 10.1093/jnci/djv250. Print 2015 Nov.

Circulating Tumor Cells and Recurrence After Primary Systemic Therapy in Stage III Inflammatory Breast Cancer.

Author information

1
Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
2
Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX. alucci@mdanderson.org.

Abstract

Inflammatory breast cancer (IBC) is rare and aggressive, with poor survival. While circulating tumor cells (CTCs) predict outcome in non-IBC patients, little data exists regarding their prognostic significance in IBC. This prospective study analyzed blood samples for CTCs from 63 stage III IBC patients to determine if CTCs present after primary systemic chemotherapy predicted relapse. CTC identification was not associated with tumor characteristics, lymph node positivity, or complete pathologic response to systemic therapy. At mean follow-up of 38 months, multivariable analysis demonstrated that detection of one or more CTCs predicted shortened relapse-free (log-rank P = 0.005, hazard ratio [HR] = 4.22, 95% confidence interval [CI] = 1.67 to 10.67, Cox P = 0.002) but not overall survival (log-rank P = 0.54, HR = 1.53, 95% CI = 0.41 to 5.79, Cox P = 0.53). All statistical tests were two-sided. In this study, CTCs after primary chemotherapy identified IBC patients at high risk for relapse.

PMID:
26374427
PMCID:
PMC4849361
DOI:
10.1093/jnci/djv250
[Indexed for MEDLINE]
Free PMC Article

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