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Eur J Hum Genet. 2016 Jun;24(6):937-43. doi: 10.1038/ejhg.2015.201. Epub 2015 Sep 16.

Origins, admixture and founder lineages in European Roma.

Author information

1
Departament de Ciències Experimentals i de la Salut, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain.
2
Unit of Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, Paris, France.
3
CNRS URA3012, Paris, France.
4
Servicio de Inmunología, Hospital Universitario Puerta de Hierro, Madrid, Spain.
5
University of Medicine and Pharmacy Craiova, Craiova, Romania.
6
University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania.
7
Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, Perth, WA, Australia.
8
Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
9
Institute of Hereditary Pathology of the Ukrainian Academy of Medical Sciences, Lviv, Ukraine.
10
Department of Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
11
Institute of Forensic Medicine, Network of Forensic Science Institutes, Budapest, Hungary.
12
Department of Neurology, Medical University-Sofia, Sofia, Bulgaria.
13
Department of Cognitive Science and Psychology, New Bulgarian University, Sofia, Bulgaria.
14
Institute of Ethnology, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Abstract

The Roma, also known as 'Gypsies', represent the largest and the most widespread ethnic minority of Europe. There is increasing evidence, based on linguistic, anthropological and genetic data, to suggest that they originated from the Indian subcontinent, with subsequent bottlenecks and undetermined gene flow from/to hosting populations during their diaspora. Further support comes from the presence of Indian uniparentally inherited lineages, such as mitochondrial DNA M and Y-chromosome H haplogroups, in a significant number of Roma individuals. However, the limited resolution of most genetic studies so far, together with the restriction of the samples used, have prevented the detection of other non-Indian founder lineages that might have been present in the proto-Roma population. We performed a high-resolution study of the uniparental genomes of 753 Roma and 984 non-Roma hosting European individuals. Roma groups show lower genetic diversity and high heterogeneity compared with non-Roma samples as a result of lower effective population size and extensive drift, consistent with a series of bottlenecks during their diaspora. We found a set of founder lineages, present in the Roma and virtually absent in the non-Roma, for the maternal (H7, J1b3, J1c1, M18, M35b, M5a1, U3, and X2d) and paternal (I-P259, J-M92, and J-M67) genomes. This lineage classification allows us to identify extensive gene flow from non-Roma to Roma groups, whereas the opposite pattern, although not negligible, is substantially lower (up to 6.3%). Finally, the exact haplotype matching analysis of both uniparental lineages consistently points to a Northwestern origin of the proto-Roma population within the Indian subcontinent.

PMID:
26374132
PMCID:
PMC4867443
DOI:
10.1038/ejhg.2015.201
[Indexed for MEDLINE]
Free PMC Article

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