The B-cell antigen receptor integrates adaptive and innate immune signals

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12145-50. doi: 10.1073/pnas.1516428112. Epub 2015 Sep 14.

Abstract

B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.

Keywords: B-cell proliferation; BCR; Foxo1; GSK3β; PI-3K.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptive Immunity / immunology*
  • Animals
  • Cell Proliferation / physiology*
  • Cell Survival / immunology
  • Cells, Cultured
  • DNA Primers / genetics
  • Electrophoretic Mobility Shift Assay
  • Flow Cytometry
  • Immunity, Innate / immunology*
  • Immunoblotting
  • Mice
  • Models, Immunological*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Real-Time Polymerase Chain Reaction
  • Receptors, Antigen, B-Cell / immunology*
  • Signal Transduction / immunology*

Substances

  • DNA Primers
  • Receptors, Antigen, B-Cell
  • Phosphatidylinositol 3-Kinases