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FASEB J. 2016 Jan;30(1):13-22. doi: 10.1096/fj.15-276337. Epub 2015 Sep 14.

Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle.

Author information

1
Center for Skeletal Muscle Research, Robert M. Berne Cardiovascular Research Center, Department of Medicine, Department of Pharmacology, and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
2
Center for Skeletal Muscle Research, Robert M. Berne Cardiovascular Research Center, Department of Medicine, Department of Pharmacology, and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia, USA zhen.yan@virginia.edu.

Abstract

Exercise training enhances physical performance and confers health benefits, largely through adaptations in skeletal muscle. Mitochondrial adaptation, encompassing coordinated improvements in quantity (content) and quality (structure and function), is increasingly recognized as a key factor in the beneficial outcomes of exercise training. Exercise training has long been known to promote mitochondrial biogenesis, but recent work has demonstrated that it has a profound impact on mitochondrial dynamics (fusion and fission) and clearance (mitophagy), as well. In this review, we discuss the various mechanisms through which exercise training promotes mitochondrial quantity and quality in skeletal muscle.

KEYWORDS:

PGC-1α; biogenesis; mitophagy; remodeling

PMID:
26370848
PMCID:
PMC6137621
DOI:
10.1096/fj.15-276337
[Indexed for MEDLINE]
Free PMC Article

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