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Andrologia. 2016 Jun;48(5):595-600. doi: 10.1111/and.12488. Epub 2015 Sep 15.

Impact of single-dose nandrolone decanoate on gonadotropins, blood lipids and HMG CoA reductase in healthy men.

Author information

1
Division of Clinical Pharmacology, Department of Laboratory Medicine/Huddinge, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden.
2
Department of Medicine/Huddinge, Karolinska Institute and Centre for Andrology and Sexual Medicine, Karolinska University Hospital, Huddinge, Sweden.

Abstract

The aim was to study the effect and time profile of a single dose of nandrolone decanoate (ND) on gonadotropins, blood lipids and HMG CoA reductase [3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR)] in healthy men. Eleven healthy male participants aged 29-46 years were given a single dose of 150 mg ND as an intramuscular dose of Deca Durabol®, Organon. Blood samples for sex hormones, lipids and HMGCR mRNA analysis were collected prior to ND administration day 0, 4 and 14. A significant suppression of luteinising hormone (LH) and follicle-stimulating hormone (FSH) was seen after 4 days. Total testosterone and bioavailable testosterone level decreased significantly throughout the observed study period. A small but significant decrease in sexual hormone-binding globulin (SHBG) was seen after 4 days but not after 14 days. Total serum (S)-cholesterol and plasma (P)-apolipoprotein B (ApoB) increased significantly after 14 days. In 80% of the individuals, the HMGCR mRNA level was increased 4 days after the ND administration. Our results show that a single dose of 150 mg ND increases (1) HMGCR mRNA expression, (2) total S-cholesterol and (3) P-ApoB level. The long-term consequences on cardiovascular risk that may appear in users remain to be elucidated.

KEYWORDS:

Blood lipids; HMG CoA reductase; gonadotropins; nandrolone decanoate

PMID:
26370185
DOI:
10.1111/and.12488
[Indexed for MEDLINE]

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