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Photodermatol. 1989 Dec;6(6):268-74.

Local increase in interleukin-1-like activity following UVB irradiation of human skin in vivo.

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Institute of Dermatology, St Thomas' Hospital, London, United Kingdom.


Using an in vivo skin chamber method, we demonstrated increased release of interleukin-1 (IL-1)-like activity at the site of irradiation with 3 times the minimal erythema dose of ultraviolet B (UVB). IL-1-like activity was estimated using the mouse thymocyte amplification assay. UVB-augmented release of IL-1-like activity peaked 1 h after irradiation and levels returned to baseline by 2 h. Release of IL-1-like activity from human skin after exposure to UV radiation may account for some of the local and systemic features of the sunburn response.

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