Format

Send to

Choose Destination
Front Neuroendocrinol. 2015 Oct;39:28-37. doi: 10.1016/j.yfrne.2015.09.001. Epub 2015 Sep 12.

The omniscient placenta: Metabolic and epigenetic regulation of fetal programming.

Author information

1
Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, 380 S. University Ave, Philadelphia, PA 19104, USA. Electronic address: bnugent@vet.upenn.edu.
2
Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, 380 S. University Ave, Philadelphia, PA 19104, USA. Electronic address: tbale@vet.upenn.edu.

Abstract

Fetal development could be considered a sensitive period wherein exogenous insults and changes to the maternal milieu can have long-term impacts on developmental programming. The placenta provides the fetus with protection and necessary nutrients for growth, and responds to maternal cues and changes in nutrient signaling through multiple epigenetic mechanisms. The X-linked enzyme O-linked-N-acetylglucosamine transferase (OGT) acts as a nutrient sensor that modifies numerous proteins to alter various cellular signals, including major epigenetic processes. This review describes epigenetic alterations in the placenta in response to insults during pregnancy, the potential links of OGT as a nutrient sensor to placental epigenetics, and the implications of placental epigenetics in long-term neurodevelopmental programming. We describe the role of placental OGT in the sex-specific programming of hypothalamic-pituitary-adrenal (HPA) axis programming deficits by early prenatal stress as an example of how placental signaling can have long-term effects on neurodevelopment.

KEYWORDS:

Epigenetics; Fetal development; Neurodevelopment; Nutrition; OGT; Placenta; Stress

PMID:
26368654
PMCID:
PMC4681645
DOI:
10.1016/j.yfrne.2015.09.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center