Format

Send to

Choose Destination
Adv Pharmacol Sci. 2015;2015:132873. doi: 10.1155/2015/132873. Epub 2015 Aug 20.

Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice.

Author information

1
Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt ; Department of Pharmacology, Faculty of Pharmacy, Tabuk University, Tabuk 71491, Saudi Arabia.
2
Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.

Abstract

Spirulina is a blue-green alga used as a dietary supplement. It has been shown to possess anti-inflammatory, antioxidant, and hepatoprotective properties. This study was designed to evaluate the antitumor effect of spirulina (200 and 800 mg/kg) against a murine model of solid Ehrlich carcinoma compared to a standard chemotherapeutic drug, 5-fluorouracil (20 mg/kg). Untreated mice developed a palpable solid tumor after 13 days. Unlike fluorouracil, spirulina at the investigated two dose levels failed to exert any protective effect. In addition, spirulina did not potentiate the antitumor effect of fluorouracil when they were administered concurrently. Interestingly, their combined administration resulted in a dose-dependent increase in mortality. The present study demonstrates that spirulina lacks antitumor effect against this model of solid Ehrlich carcinoma and increased mortality when combined with fluorouracil. However, the implicated mechanism is still elusive.

Supplemental Content

Full text links

Icon for Hindawi Publishing Corporation Icon for PubMed Central
Loading ...
Support Center