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J Neurosci Methods. 2015 Dec 30;256:184-97. doi: 10.1016/j.jneumeth.2015.09.004. Epub 2015 Sep 10.

Dynamic spatiotemporal brain analyses using high-performance electrical neuroimaging, Part II: A step-by-step tutorial.

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High-Performance Electrical Neuroimaging Laboratory, Biological Science Division, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA. Electronic address:
Center for Cognitive and Social Neuroscience, University of Chicago, Chicago, IL 60637, USA. Electronic address:


Our recently published analytic toolbox (Cacioppo et al., 2014), running under MATLAB environment and Brainstorm, offered a theoretical framework and set of validation studies for the automatic detection of event-related changes in the global pattern and global field power of electrical brain activity. Here, we provide a step-by-step tutorial of this toolbox along with a detailed description of analytical plans (aka the Chicago Electrical Neuroimaging Analytics, CENA) for the statistical analysis of brain microstate configuration and global field power in within and between-subject designs. Available CENA functions include: (1) a difference wave function; (2) a high-performance microsegmentation suite (HPMS), which consists of three specific analytic tools: (i) a root mean square error (RMSE) metric for identifying stable states and transition states across discrete event-related brain microstates; (ii) a similarity metric based on cosine distance in n dimensional sensor space to determine whether template maps for successive brain microstates differ in configuration of brain activity, and (iii) global field power (GFP) metrics for identifying changes in the overall level of activation of the brain; (3) a bootstrapping function for assessing the extent to which the solutions identified in the HPMS are robust (reliable, generalizable) and for empirically deriving additional experimental hypotheses; and (4) step-by-step procedures for performing a priori contrasts for data analysis. CENA is freely available for brain data spatiotemporal analyses at, with sample data, user tutorial videos, and documentation.


Biomarkers; Bootstrapping; Brain electrodynamics; Chicago Electrical Neuroimaging Analytics (CENA); Cosine distance metric; EEG/ERP; Electrical neuroimaging; Freeware; Global field power; High-performance microsegmentation suite (HPMS); Root mean square error; Tutorial

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