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J Mol Endocrinol. 2015 Oct;55(2):R11-22. doi: 10.1530/JME-15-0146.

Stress kinases in the modulation of metabolism and energy balance.

Author information

1
Myocardial Pathophysiology AreaFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC, C/Melchor Fernandez Almagro, 2, 28029 Madrid, SpainDepartment of Immunology and OncologyCentro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, Madrid, Spain Myocardial Pathophysiology AreaFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC, C/Melchor Fernandez Almagro, 2, 28029 Madrid, SpainDepartment of Immunology and OncologyCentro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, Madrid, Spain.
2
Myocardial Pathophysiology AreaFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC, C/Melchor Fernandez Almagro, 2, 28029 Madrid, SpainDepartment of Immunology and OncologyCentro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, Madrid, Spain gsabio@cnic.es.

Abstract

Obesity is a new global pandemic, with growing incidence and prevalence. This disease is associated with increased risk of several pathologies, including diabetes, cardiovascular diseases, and cancer. The mechanisms underlying obesity-associated metabolic changes are the focus of efforts to identify new therapies. Stress-activated protein kinases (SAPK), including cJun N-terminal kinases (JNKs) and p38, are required for cellular responses to metabolic stress and therefore might contribute to the pathogenesis of obesity. Tissue-specific knockout models support a cell-type-specific role for JNK isoforms, in particular JNK1, highlighting its importance in cell homeostasis and organ crosstalk. However, more efforts are needed to elucidate the specific roles of other JNK isoforms and p38 family members in metabolism and obesity. This review provides an overview of the role of SAPKs in the regulation of metabolism.

KEYWORDS:

JNK; SAPK; adipose tissue; brain and signal transduction; metabolism; obesity; p38; stress

PMID:
26363062
PMCID:
PMC5176079
DOI:
10.1530/JME-15-0146
[Indexed for MEDLINE]
Free PMC Article

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