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Clin Cancer Res. 2015 Nov 1;21(21):4747-9. doi: 10.1158/1078-0432.CCR-15-1397. Epub 2015 Sep 11.

Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations.

Author information

1
Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. rani_george@dfci.harvard.edu.

Abstract

Bellini and colleagues demonstrate the importance of next-generation sequencing to uncover subclonal anaplastic lymphoma kinase (ALK) mutations in neuroblastoma. Although the significance of these subclonal aberrations is not yet understood, deep sequencing could identify patients whose tumors may respond to ALK inhibitors.

PMID:
26362998
PMCID:
PMC4631645
DOI:
10.1158/1078-0432.CCR-15-1397
[Indexed for MEDLINE]
Free PMC Article

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