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Seizure. 2015 Sep;31:12-8. doi: 10.1016/j.seizure.2015.06.015. Epub 2015 Jul 3.

Familial epilepsy in Algeria: Clinical features and inheritance profiles.

Author information

1
Department of Neurology, University Hospital of Oran, Algeria. Electronic address: amina.chentouf@yahoo.com.
2
Department of Psychiatry, University Hospital of Oran, Oran, Algeria.
3
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland; Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, Geneva, Switzerland.
4
Department of Neurology, University Hospital of Oran, Algeria.
5
Department of Neurology, Benaknoun University Hospital, Algiers, Algeria.
6
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
7
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland; Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, Geneva, Switzerland; Institute of Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland.

Abstract

PURPOSE:

To document the clinical characteristics and inheritance pattern of epilepsy in multigeneration Algerian families.

METHODS:

Affected members from extended families with familial epilepsy were assessed at the University Hospital of Oran in Algeria. Available medical records, neurological examination, electroencephalography and imaging data were reviewed. The epilepsy type was classified according to the criteria of the International League Against Epilepsy and modes of inheritance were deduced from pedigree analysis.

RESULTS:

The study population included 40 probands; 23 male (57.5%) and 17 female subjects (42.5%). The mean age of seizure onset was 9.5 ± 6.1 years. According to seizure onset, 16 patients (40%) had focal seizures and 20 (50%) had generalized seizures. Seizure control was achieved for two patients (5%) for 10 years, while 28 (70%) were seizure-free for 3 months. Eleven patients (27.5%) had prior febrile seizures, 12 were diagnosed with psychiatric disorders and four families had syndromic epilepsy. The consanguinity rate among parents of affected was 50% with phenotypic concordance observed in 25 families (62.5%). Pedigree analysis suggested autosomal dominant (AD) inheritance with or without reduced penetrance in 18 families (45%), probable autosomal recessive (AR) inheritance in 14 families (35%), and an X-linked recessive inheritance in one family.

CONCLUSION:

This study reveals large Algerian families with multigenerational inheritance of epilepsy. Molecular testing such as exome sequencing would clarify the genetic basis of epilepsy in some of our families.

KEYWORDS:

Algeria; Consanguinity; Familial epilepsy; Inherited epilepsy; Pedigree

PMID:
26362371
DOI:
10.1016/j.seizure.2015.06.015
[Indexed for MEDLINE]
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