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Mol Cell Biochem. 2016 Jan;411(1-2):95-105. doi: 10.1007/s11010-015-2571-3. Epub 2015 Sep 11.

The effects of chronic administration of nandrolone decanoate on redox status in exercised rats.

Author information

1
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
2
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia.
3
College of Health Studies in Cuprija, Cuprija, Serbia.
4
School of Medicine, University of Belgrade, Belgrade, Serbia.
5
Institute of Medical Physiology "Richard Burian", School of Medicine, University of Belgrade, Belgrade, Serbia.
6
Department of Human Pathology, 1st Moscow State Medical University I.M. Sechenov, Moscow, Russia.
7
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia. drvladakgbg@yahoo.com.

Abstract

For the past 40 years, anabolic-androgenic steroids have been used by a wide variety of athletes with the hope of improving their training, endurance, and performance. The aim of this study was to examine the chronic effects of nandrolone decanoate (20 mg/kg, s.c, Deca-Durabolin DECA(®)) on oxidative stress biomarkers in the hearts of sedentary and exercised rats. The male Wistar albino rats (n = 180, four groups with three subgroups, 15 per subgroup, age 10 weeks, body mass 200-220 g) were sacrificed, and in the collected samples of blood, the following markers of oxidative stress were measured spectrophotometrically: (1) index of lipid peroxidation (measured as TBARS-thiobarbituric acid reactive substances); (2) nitrites (NO2 (-)); (3) hydrogen peroxide (H2O2); (4) superoxide anion radical (O2 (-)), and superoxide dismutase, catalase, and glutathione reductase. The results clearly show that the impact of ND alone, or in combination with physical training in general, is mildly pro-oxidative. The chronic physical training probably induces the protective antioxidant enzyme system , which may be of clinical interest when faced with overdosage of this drug.

KEYWORDS:

Exercise; Nandrolone decanoate; Rats; Redox status

PMID:
26361780
DOI:
10.1007/s11010-015-2571-3
[Indexed for MEDLINE]

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