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Nat Rev Drug Discov. 2015 Oct;14(10):721-31. doi: 10.1038/nrd4627. Epub 2015 Sep 11.

Zebrafish as tools for drug discovery.

MacRae CA1,2,3,4, Peterson RT3,4,5,6.

Author information

1
Cardiovascular Medicine and Network Medicine Divisions, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
2
Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.
3
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
4
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
5
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
6
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

The zebrafish has become a prominent vertebrate model for disease and has already contributed to several examples of successful phenotype-based drug discovery. For the zebrafish to become useful in drug development more broadly, key hurdles must be overcome, including a more comprehensive elucidation of the similarities and differences between human and zebrafish biology. Recent studies have begun to establish the capabilities and limitations of zebrafish for disease modelling, drug screening, target identification, pharmacology, and toxicology. As our understanding increases and as the technologies for manipulating zebrafish improve, it is hoped that the zebrafish will have a key role in accelerating the emergence of precision medicine.

PMID:
26361349
DOI:
10.1038/nrd4627
[Indexed for MEDLINE]
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