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Cell. 2015 Sep 10;162(6):1186-90. doi: 10.1016/j.cell.2015.08.038.

Releasing the Brakes on Cancer Immunotherapy.

Author information

1
Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; The Howard Hughes Medical Institute. Electronic address: dan.littman@med.nyu.edu.

Abstract

This year's Lasker∼DeBakey Clinical Research Award goes to James Allison for discovering that antibody blockade of the T cell molecule CTLA-4 unleashes the body's immune response against malignant tumors. This has led to development of multiple "immune checkpoint therapies" that are prolonging and saving the lives of thousands of cancer patients.

PMID:
26359975
DOI:
10.1016/j.cell.2015.08.038
[Indexed for MEDLINE]
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