Format

Send to

Choose Destination
Arthritis Care Res (Hoboken). 2016 Apr;68(4):511-6. doi: 10.1002/acr.22714.

Association of Body Mass Index With Incidence and Progression of Knee Effusion on Magnetic Resonance Imaging and on Knee Examination.

Author information

1
University of British Columbia, Vancouver, British Columbia, Canada.
2
Arthritis Research Canada, Vancouver, British Columbia, Canada.
3
Boston University, Boston, Massachusetts.
4
University of British Columbia and Arthritis Research Canada, Vancouver, British Columbia, Canada.
5
University of British Columbia and CIHR Canadian HIV Trials Network, Vancouver, British Columbia, Canada.
6
University of British Columbia and Centre for Health Evaluation and Outcome Sciences, Vancouver, British Columbia, Canada.
7
University of British Columbia and Vancouver General Hospital.

Abstract

OBJECTIVE:

To determine the association of body mass index (BMI) with incidence and progression of knee effusion on magnetic resonance imaging (MRI) and physical examination (PE) in a longitudinal cohort with knee pain.

METHODS:

A population-based cohort was assessed at baseline and 3 years (n = 163). BMI was categorized as normal (<25), overweight (25-29.9), and obese (≥30). Knee effusion was graded as 0-3 (absent/mild/moderate/severe) on MRI and 0-1 (absent/present) on PE. Progression of MRI effusion (MRIeff ) was an increase of ≥1 grade in those with grade 1 or 2 at baseline. Incident MRIeff and PE effusion (PEeff ) were any effusion at followup (>0) in those with grade 0 at baseline. A second type of incident MRIeff was effusion grade ≥2 at followup in those with grade <2 at baseline. Exponential regression analysis was used, adjusted for age, sex, and radiographic severity.

RESULTS:

Incident MRIeff ≥1, incident MRIeff ≥2, incident PEeff , and progression of MRIeff were seen in 14 of 73 (19%), 18 of 140 (13%), 26 of 127 (20%), and 18 of 86 (21%), respectively. There was a borderline statistical association of obesity with progression of MRIeff (hazard ratio [HR] 3.3 [95% confidence interval (95% CI) 1.0-11.2]) and with incident MRIeff ≥2 (HR 3.4 [95% CI 1.0-11.5]). BMI was not associated with incident MRIeff ≥1 (HR overweight 1.1 [95% CI 0.3-3.6], obese 1.0 [95% CI 0.2-5.0]). Overweight was associated with incident PEeff (HR 4.5 [95% CI 1.4-14.2]), while obesity was not statistically significant (HR 3.1 [95% CI 0.9-11.1]).

CONCLUSION:

Obesity was a risk factor for incident and progressive knee effusion in this population-based cohort. These findings highlight an important link between obesity and inflammation in knee osteoarthritis.

PMID:
26359653
DOI:
10.1002/acr.22714
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center