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Semin Vasc Surg. 2015 Mar;28(1):6-14. doi: 10.1053/j.semvascsurg.2015.07.003. Epub 2015 Jul 17.

Pathogenesis of venous ulcer.

Author information

1
Jobst Vascular Institute, 2109 Hughes Drive, Toledo, OH 43606. Electronic address: Anthony.ComerotaMD@ProMedica.org.
2
Jobst Vascular Institute, 2109 Hughes Drive, Toledo, OH 43606.

Abstract

The underlying pathophysiology of venous ulceration is venous hypertension, which initiates a complex cascade of cellular humeral events that are then magnified by genetic factors. Hemodynamic abnormalities are features of primary and secondary chronic venous diseases that lead to disease progression. Through a sequence of events, some patients develop venous leg ulcers, if the process is not interrupted. The exact science of the pathophysiology of the progression of chronic venous disease to venous leg ulcers is still in its infancy, but the framework for future study has been established.

[Indexed for MEDLINE]

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