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Eur Respir J. 2015 Nov;46(5):1308-21. doi: 10.1183/13993003.00779-2015. Epub 2015 Sep 10.

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.

Collaborators (211)

Tariq K, Dennison P, Behndig AF, van Aalderen W, Lutter R, Wagener A, van Drunen K, Hekking PP, Brinkman P, Zwinderman K, Mores N, Santini G, Valente S, Rossios C, Gibeon D, Hoda U, Rocha JP, Sogbesan A, Gent J, Menzies-Gow A, Campagna D, Bigler J, Boedigheimer MJ, Yu W, Hu X, Fichtner K, Nething K, Erzen D, Sigmund R, Gahlemann M, Riemann K, Berton A, Klüglich M, Hohlfeld J, Badorrek P, Faulenbach C, James A, Lantz AS, Henriksson E, Middelveld R, Strandberg K, Galffy G, Szentkereszty M, Smith KM, Tamasi L, De Meulder B, Lefaudeux D, Adcock IM, Ahmed H, Allen D, Auffray C, Badorrek P, Ballereau S, Bansal AT, Behndig AF, Bel EH, Berglind A, Berton A, Bigler J, Bisgaard H, Boedigheimer MJ, Brinkman P, Bucchioni E, Bush A, Bønnelykke K, Chaiboonchoe A, Campagna D, Caruso M, Casaulta C, Chanez P, Chung KF, Compton CH, Corfield J, Dahlen SE, Dahlén B, De Meulder B, Delin I, Dennison P, Djukanovic R, Dyson K, El Hadjam L, Erpenbeck VJ, Erzen D, Faulenbach C, Fichtner K, Fitch N, Fleming LJ, Formaggio E, Fowler SJ, Frey U, Gahlemann M, Galffy G, Garissi D, Garret T, Geiser T, Gerhardsson de Verdier M, von Garnier C, Gibeon D, Guillmnt-Farry E, Guo Y, Hashimoto S, Hedlin G, Hekking PW, Henriksson E, Higenbottam T, Hoda U, Horváth I, Howarth P, Hu X, James A, Jeyasingham E, Johnston K, Jullian N, Kerry G, Klüglich M, Knox AJ, Konradsen JR, Krueger L, Krug N, Larsson LX, Latzin P, Lazarinis N, Lefaudeux D, Lemonnier N, Lutter R, Mazein A, McEvoy L, Menzies-Gow A, Middelveld RJ, Montuschi P, Mores N, Murray CS, Musial J, Myles D, Nething K, Nihlén U, Niven R, Nordlund B, Nsubuga S, Pahus L, Pandis I, Pellet J, Pison C, Praticò G, Puig Valls M, Riemann K, Roberts G, Rocha JP, Rossios C, Rowe A, Sandström T, Santini G, Saqi M, Scott S, Sehgal N, Seibold W, Shaw DE, Sigmund R, Singer F, Sogbesan A, Sousa AR, Söderman P, Spycher F, Stephan S, Sterk PJ, Stokholm J, Strandberg K, Sunthar S, Szentkereszty M, Tamasi L, Tariq K, Valente S, van Aalderen WM, van Drunen CM, Vestbo J, Vissing NH, Vyas A, Wagener AH, Wagers SS, Wilson SJ, Yu W, Zetterquist W, Zolkipli Z, Zwinderman AH, Prins JB, Gahlemann M, Visintin L, Evans H, Puhl M, Buzermaniene L, Hudson V, Bond L, de Boer P, Widdershoven G, Sigmund R, Roberts A, Supple D, Hamerlijnck D, Negus J, Kamphuis J, Sergison L, Visintin L, de Boer P, Onstein S, MacNee W, Bernardini R, Bont L, Wecksell PA, de Boer P, Gahlemann M, Sigmund R.

Author information

1
Respiratory Research Unit, University of Nottingham, Nottingham, UK Joint first authors dominic.shaw@nottingham.ac.uk.
2
Respiratory Therapeutic Unit, GSK, Stockley Park, UK Joint first authors.
3
Respiratory and Allergy Research Group, University of Manchester, Manchester, UK.
4
National Heart and Lung Institute, Imperial College, London, UK.
5
NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, UK Faculty of Medicine, University of Southampton, Southampton, UK The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK.
6
AstraZeneca R&D, Mölndal, Sweden Areteva R&D, Nottingham, UK.
7
Data Science Institute, South Kensington Campus, Imperial College London, London, UK.
8
Acclarogen Ltd, St John's Innovation Centre, Cambridge, UK.
9
Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
10
European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
11
Respiratory Therapeutic Unit, GSK, Stockley Park, UK.
12
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
13
Chiesi Pharmacueticals SPA, Parma, Italy.
14
Dept of Clinical and Experimental Medicine Hospital University, University of Catania, Catania, Italy.
15
Département des Maladies Respiratoires, Laboratoire d'immunologie, Aix Marseille Université Marseille, Marseille, France.
16
Lung/Allergy Clinic, Karolinska University Hospital Huddinge, Stockholm, Sweden.
17
The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
18
CROMSOURCE, Stirling, UK.
19
University Children's Hospital Basel, Basel, Switzerland.
20
University Hospital Bern, Bern, Switzerland.
21
AstraZeneca R&D, Mölndal, Sweden.
22
Dept of Women's and Children's Health and Center for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
23
UK Clinical Operations, GSK, Stockley Park, UK.
24
Allergy Therapeutics, West Sussex, UK.
25
Dept of Pulmonology, Semmelweis University, Budapest, Hungary.
26
Respiratory Research Unit, University of Nottingham, Nottingham, UK.
27
Fraunhofer Institute for Toxicology and Experimental Medicine Hannover, Hannover, Germany.
28
Translational Medicine - Respiratory Profiling, Novartis Institutes for BioMedical Research, Basel, Switzerland.
29
Respiratory and Allergic Diseases, Product Development Immunology, Genentech, San Francisco, CA, USA.
30
Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy.
31
Dept of Medicine, Jagiellonian University Medical College, Krakow, Poland.
32
Respiratory Therapy Area Unit, GlaxoSmithKline, Stevenage, UK.
33
Assistance publique des Hôpitaux de Marseille, Hôpital NORD, Clinique des bronches, allergies et sommeil, Marseille, France.
34
Dept of Medicine, Dept of Public Health and Clinical Medicine Respiratory Medicine Unit, Umeå University, Umeå, Sweden.
35
Boehringer Ingelheim Pharma GmbH & Co., Ingelheim, Germany.
36
University Children's Hospital Zurich, Zurich, Switzerland.
37
Respiratory Research Group, Manchester Academic Health Science Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, UK.
38
The Danish Pediatric Asthma Center, University of Copenhagen, Copenhagen, Denmark.
39
University Hospital Bern, Bern, Switzerland Tiefenau Hospital, Bern, Switzerland.
40
National Heart and Lung Institute, Imperial College, London, UK Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, UK.
41
BioSci Consulting, Maasmechelen, Belgium.
42
Janssen Research and Development Ltd, High Wycombe, UK.
43
NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
44
Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands Joint last authors.
45
National Heart and Lung Institute, Imperial College, London, UK Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, UK Joint last authors.

Abstract

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of "omic" datasets that are at the core of this systems medicine approach.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01982162.

PMID:
26357963
DOI:
10.1183/13993003.00779-2015
[Indexed for MEDLINE]
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