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Sultan Qaboos Univ Med J. 2015 Aug;15(3):e305-16. doi: 10.18295/squmj.2015.15.03.002. Epub 2015 Aug 24.

The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer's Disease.

Author information

1
Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran; ; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
2
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;
3
Health & Social Services Sector, The Research Council Oman, Muscat, Oman;
4
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Alzheimer's disease (AD), a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofibrillary tangles and neuro-inflammation. Inflammation of the brain is a key pathological hallmark of AD. Thus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators. In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain. This review provides an overview of the functions and activities of inflammatory mediators in AD. An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the field of AD and similar diseases.

KEYWORDS:

Acute Phase Proteins; Alzheimer’s Disease; Chemokines; Complement System Proteins; Cytokines; Inflammation Mediators

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