Format

Send to

Choose Destination
Medicine (Baltimore). 2015 Sep;94(36):e1433. doi: 10.1097/MD.0000000000001433.

Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients.

Author information

1
From the Department of Dermatology, Venereology and Allergology, Georg August University of Göttingen, Robert-Koch-Str. 40, D-37075 Göttingen (LK, HPB, KMT, MPS); Department of Medical Statistics, Georg August University of Göttingen, Humboldtallee 32 37073 Göttingen (AZ); Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany (IS, BV, RG); Department of Dermatology, Venereology and Allergology, Klinikum Hildesheim GmbH, Senator-Braun-Allee 33, 31135 Hildesheim, Germany (CM); and Department of Dermatology and Allergology, Klinikum Augsburg, Germany, Sauerbruchstr. 6, D-86179 Augsburg (HS).

Abstract

The objective of this study was to analyze different types of nodal basin recurrence after sentinel lymph node biopsy (SLNB) for melanoma.

PATIENTS AND METHODS:

Kaplan-Meier estimates and the Cox proportional hazards model were used to study 2653 patients from 3 German melanoma centers retrospectively.The estimated 5-year negative predictive value of SLNB was 96.4%. The estimated false-negative (FN) rates after 1, 2, 3, 5, and 10 years were 2.5%, 4.6%, 6.4%, 8.7%, and 12.6%, respectively. Independent factors associated with false negativity were older age, fewer SLNs excised, and head or neck location of the primary tumor. Compared with SLN-positive patients, the FNs had a significantly lower survival. In SLN-positive patients undergoing completion lymphadenectomy (CLND), the 5-year nodal basin recurrence rate was 18.3%. The recurrence rates for axilla, groin, and neck were 17.2%, 15.5%, and 44.1%, respectively. Significant factors predicting local relapse after CLND were older age, head, or neck location of the primary tumor, ulceration, deeper penetration of the metastasis into the SLN, tumor-positive CLND, and >2 lymph node metastases. All kinds of nodal relapse were associated with a higher prevalence of in-transit metastases.The FN rate after SLNB steadily increases over the observation period and should, therefore, be estimated by the Kaplan-Meier method. False-negativity is associated with fewer SLNs excised. The beneficial effect of CLND on nodal basin disease control varies considerably across different risk groups. This should be kept in mind about SLN-positive patients when individual decisions on prophylactic CLND are taken.

PMID:
26356697
PMCID:
PMC4616624
DOI:
10.1097/MD.0000000000001433
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wolters Kluwer Icon for PubMed Central
Loading ...
Support Center