Format

Send to

Choose Destination
IEEE/ACM Trans Comput Biol Bioinform. 2014 Mar-Apr;11(2):325-35. doi: 10.1109/TCBB.2014.2309592.

Distance-Based Phylogenetic Methods Around a Polytomy.

Abstract

Distance-based phylogenetic algorithms attempt to solve the NP-hard least-squares phylogeny problem by mapping an arbitrary dissimilarity map representing biological data to a tree metric. The set of all dissimilarity maps is a Euclidean space properly containing the space of all tree metrics as a polyhedral fan. Outputs of distance-based tree reconstruction algorithms such as UPGMA and neighbor-joining are points in the maximal cones in the fan. Tree metrics with polytomies lie at the intersections of maximal cones. A phylogenetic algorithm divides the space of all dissimilarity maps into regions based upon which combinatorial tree is reconstructed by the algorithm. Comparison of phylogenetic methods can be done by comparing the geometry of these regions. We use polyhedral geometry to compare the local nature of the subdivisions induced by least-squares phylogeny, UPGMA, and neighbor-joining when the true tree has a single polytomy with exactly four neighbors. Our results suggest that in some circumstances, UPGMA and neighbor-joining poorly match least-squares phylogeny.

PMID:
26355780
DOI:
10.1109/TCBB.2014.2309592
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for IEEE Engineering in Medicine and Biology Society
Loading ...
Support Center