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Muscle Nerve. 2016 May;53(5):779-88. doi: 10.1002/mus.24906. Epub 2016 Mar 28.

High-intensity resistance training attenuates dexamethasone-induced muscle atrophy.

Author information

1
Joint Graduate Program in Physiological Sciences, PIPGCF UFscar/UNESP, Federal University of Sao Carlos/Sao Paulo State University, Sao Carlos, São Paulo, Brazil.
2
Department of Physical Education, Science Faculty, São Paulo State University, Avenida Eng. Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa, Bauru, São Paulo, Brazil.
3
Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
4
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

Abstract

INTRODUCTION:

In this study we investigated the effects of high-intensity resistance training (RT) on dexamethasone (DEX)-induced muscle atrophy in flexor hallucis longus (FHL), tibialis anterior (TA), and soleus (SOL) muscles.

METHODS:

Rats underwent either high-intensity RT or were kept sedentary. In the last 10 days they received either DEX (0.5 mg/kg/day, intraperitoneally) or saline.

RESULTS:

DEX reduced body weight (-21%), food intake (-28%), FHL and TA muscle mass (-20% and -18%, respectively), and increased muscle-specific ring finger 1 (MuRF-1) protein level (+37% and +45.5%). RT attenuated FHL muscle atrophy through a combination of low increase in MuRF-1 protein level (-3.5%) and significant increases in mammalian target of rapamycin (mTOR) (+63%) and p70S6K (+46% and +49% for control and DEX, respectively) protein levels.

CONCLUSION:

RT attenuated DEX-induced muscle atrophy through a combination of increases in mTOR and p70S6K protein levels and a low increase in MuRF-1 protein level.

KEYWORDS:

glucocorticoids; ladder climbing; muscle atrophy; resistance training; skeletal muscle

PMID:
26355638
DOI:
10.1002/mus.24906
[Indexed for MEDLINE]

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