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Mediators Inflamm. 2015;2015:569714. doi: 10.1155/2015/569714. Epub 2015 Aug 19.

An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes.

Author information

1
Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca MútuaTerrassa, Mutua de Terrassa Hospital, Sant Antoni 19, Terrassa, 08221 Barcelona, Spain.
2
Neurology Department, Mutua de Terrassa Hospital, Terrassa, 08221 Barcelona, Spain.
3
Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona, Spain.

Abstract

Inflammation has been associated with atherothrombotic stroke and recently with cardioembolic stroke. Different genetic risk factors have been specifically associated with the subtypes of ischemic stroke (cardioembolic, atherothrombotic, and lacunar). However, there are no studies that have generated genetic risk scores for the different subtypes of ischemic stroke using polymorphisms associated with inflammation.

METHODS:

We have analyzed 68 polymorphisms of 30 inflammatory mediator genes in 2,685 subjects: 1,987 stroke cases and 698 controls. We generated a genetic scoring system with the most significant polymorphisms weighted by the odds ratio of every polymorphism and taken into consideration the stroke subtype.

RESULTS:

Three polymorphisms, rs1205 (CRP gene), rs1800779, and rs2257073 (NOS3 gene), were associated with cardioembolic stroke (p value <0.05). The score generated was only associated with the cardioembolic stroke subtype (p value: 0.001) and was replicated in an independent cohort (p value: 0.017). The subjects with the highest score presented a cardioembolic stroke in 92.2% of the cases (p value: 0.002).

CONCLUSION:

The genetics of inflammatory markers is more closely associated with cardioembolic strokes than with atherothrombotic or lacunar strokes. The genetic risk scoring system could be useful in the prediction and differentiation of ischemic stroke; however, it might be specific to particular ischemic stroke subtypes.

PMID:
26355258
PMCID:
PMC4556875
DOI:
10.1155/2015/569714
[Indexed for MEDLINE]
Free PMC Article

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