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Cold Spring Harb Perspect Biol. 2015 Sep 9;8(3):a020495. doi: 10.1101/cshperspect.a020495.

The Nodes of Ranvier: Molecular Assembly and Maintenance.

Author information

1
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
2
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).

PMID:
26354894
PMCID:
PMC4772103
DOI:
10.1101/cshperspect.a020495
[Indexed for MEDLINE]
Free PMC Article

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