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J Pathol. 2016 Jan;238(2):152-65. doi: 10.1002/path.4632. Epub 2015 Oct 9.

Cross-species models of human melanoma.

Author information

1
Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.
2
MRC Human Genetics Unit, The MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
3
Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road E, Guelph, Ontario, N1G 2W1, Canada.
4
Rossdales Equine Hospital, Cotton End Road, Exning, Newmarket, Suffolk, CB8 7NN, UK.
5
Pathology Department, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
6
Centre for Comparative Pathology, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, UK.

Abstract

Although transformation of melanocytes to melanoma is rare, the rapid growth, systemic spread, as well as the chemoresistance of melanoma present significant challenges for patient care. Here we review animal models of melanoma, including murine, canine, equine, and zebrafish models, and detail the immense contribution these models have made to our knowledge of human melanoma development, and to melanocyte biology. We also highlight the opportunities for cross-species comparative genomic studies of melanoma to identify the key molecular events that drive this complex disease.

KEYWORDS:

cross-species analysis; genome analysis; melanoma

PMID:
26354726
PMCID:
PMC4832391
DOI:
10.1002/path.4632
[Indexed for MEDLINE]
Free PMC Article

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