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J Biol Chem. 2015 Oct 30;290(44):26422-9. doi: 10.1074/jbc.R115.665869. Epub 2015 Sep 9.

The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters.

Author information

1
From the Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892-4256.
2
the Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, and.
3
the Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850.
4
From the Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892-4256, samelsonl@helix.nih.gov.

Abstract

Since the cloning of the critical adapter, LAT (linker for activation of T cells), more than 15 years ago, a combination of multiple scientific approaches and techniques continues to provide valuable insights into the formation, composition, regulation, dynamics, and function of LAT-based signaling complexes. In this review, we will summarize current views on the assembly of signaling complexes nucleated by LAT. LAT forms numerous interactions with other signaling molecules, leading to cooperativity in the system. Furthermore, oligomerization of LAT by adapter complexes enhances intracellular signaling and is physiologically relevant. These results will be related to data from super-resolution microscopy studies that have revealed the smallest LAT-based signaling units and nanostructure.

KEYWORDS:

T-cell; adaptor protein; cooperativity; immunology; signal transduction

PMID:
26354432
PMCID:
PMC4646300
DOI:
10.1074/jbc.R115.665869
[Indexed for MEDLINE]
Free PMC Article

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