Format

Send to

Choose Destination
Epilepsy Res. 2015 Oct;116:79-85. doi: 10.1016/j.eplepsyres.2015.06.017. Epub 2015 Jul 10.

Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study.

Author information

1
Department of Radiology, Shenzhen Children's Hospital, Guangdong, China; Department of Radiology, University of Wisconsin, Madison, USA. Electronic address: homerzeng@126.com.
2
Department of Medical Physics, University of Wisconsin, Madison, USA. Electronic address: camille.garcia23@gmail.com.
3
Department of Radiology, University of Wisconsin, Madison, USA. Electronic address: vnair@uwhealth.org.
4
Department of Neurology, Shenzhen Children's Hospital, Guangdong, China. Electronic address: 2680224170@qq.com.
5
Department of Neurology, Shenzhen Children's Hospital, Guangdong, China. Electronic address: liaojianxiang@vip.sina.com.
6
Department of Radiology, University of Wisconsin, Madison, USA; Neurosciences Training Program, University of Wisconsin, Madison, USA. Electronic address: cla.wisc@gmail.com.
7
Department of Neurology, Shenzhen Children's Hospital, Guangdong, China. Electronic address: chenli2000@126.com.
8
Department of Radiology, Shenzhen Children's Hospital, Guangdong, China. Electronic address: ganyungen@yahoo.com.
9
Department of Neurology, Shenzhen Children's Hospital, Guangdong, China. Electronic address: fwen62@126.com.
10
Department of Neurology, University of Wisconsin, Madison, USA. Electronic address: hermann@neurology.wisc.edu.
11
Department of Radiology, University of Wisconsin, Madison, USA; Department of Medical Physics, University of Wisconsin, Madison, USA; Neurosciences Training Program, University of Wisconsin, Madison, USA; Department of Neurology, University of Wisconsin, Madison, USA. Electronic address: VPrabhakaran@uwhealth.org.

Abstract

OBJECTIVE:

The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data.

METHODS:

Resting state fMRI data was collected from three groups of children aged 6-13, including new onset drug naïve BECTS, chronic BECTS with medication, and HC; the data analyzed by ReHo method. Mandarin school exams scores were acquired and compared across groups.

RESULTS:

There were three main findings. Firstly, compared with HC, abnormally increased ReHo was observed in bilateral sensorimotor regions in new onset BECTS which normalized or even reversed in the chronic BECTS group. Secondly, enhanced ReHo was found in the left frontal language region in the two BECTS groups, with even higher ReHo value in the chronic group. Lastly, decreased ReHo was found in regions of the default mode network (DMN), bilateral occipital lobes and cerebellum in both the new onset and chronic BECTS groups, lower in chronic BECTS. Behavioral analyses of school scores showed the chronic BECTS group presented significantly lower scores compared to HC (p<.05).

SIGNIFICANCE:

The coherence of low frequency fluctuations is disrupted in sensorimotor, language and DMN-related regions in new-onset BECTS. Some of these effects seem to be selectively normalized in chronic BECTS, thus allowing us to explore possible chronicity and AED-induced effects on BECTS. Abnormal ReHo in left language and DMN regions could be responsible for impairments of cognitive function.

KEYWORDS:

BECTS; Epilepsy; Pediatric; Regional homogeneity; Resting state; fMRI

PMID:
26354170
PMCID:
PMC4567694
DOI:
10.1016/j.eplepsyres.2015.06.017
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center