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Int J Surg Pathol. 2016 Apr;24(2):103-7. doi: 10.1177/1066896915605179. Epub 2015 Sep 9.

Ki67 Heterogeneity in Estrogen Receptor-Positive Breast Cancers: Which Tumor Type Has the Most Heterogeneity?

Author information

1
Departments of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan.
2
Departments of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan yoshiyahorimoto@hotmail.com.
3
Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.

Abstract

Heterogeneity of Ki67 expression, often seen in breast cancer, can make evaluation of the expression of this marker difficult and give rise to confusion when considering adjuvant treatments for patients. Herein, we investigated estrogen receptor-positive breast cancers to reveal the tumor characteristics associated with Ki67 heterogeneity. Surgical specimens from 85 invasive ductal carcinomas of no special type and 13 invasive lobular carcinomas were examined. We first calculated the differences between Ki67 expression in a hot spot and those in 4 random fields on the same slide. We then evaluated Ki67 heterogeneity within the tumor, based on these differences. Among clinicopathological factors, solid-tubular carcinoma, an architectural growth pattern subtype of invasive ductal carcinoma, correlated with high Ki67 heterogeneity (P < .05). Our results indicate that we might need to be aware of histological patterns when selecting appropriate microscopic fields for evaluating Ki67 expression.

KEYWORDS:

Ki67; breast cancer; heterogeneity; luminal type

PMID:
26353854
DOI:
10.1177/1066896915605179
[Indexed for MEDLINE]

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