Format

Send to

Choose Destination
Ann Rheum Dis. 2016 Jan;75(1):23-9. doi: 10.1136/annrheumdis-2014-207169. Epub 2015 Sep 9.

Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose.

Author information

1
Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, South Australia University of Adelaide, The Health Observatory, Adelaide, South Australia.
2
Royal North Shore Hospital, Institute of Bone and Joint Research, St Leonards, New South Wales, Australia.
3
Menzies Research Institute, Hobart, Tasmania, Australia.
4
Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, South Australia.
5
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia.

Abstract

OBJECTIVES:

To determine whether high-dose fish oil is superior to low-dose supplementation for symptomatic and structural outcomes in knee osteoarthritis (OA).

METHODS:

A randomised, double-blind, multicentre trial enrolled 202 patients with knee OA and regular knee pain. They were randomised 1:1 to high-dose fish oil (4.5 g omega-3 fatty acids) 15 mL/day or (2) low-dose fish oil (blend of fish oil and sunola oil; ratio of 1:9, 0.45 g omega-3 fatty acids) 15 mL/day. The primary endpoints were Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score at 3, 6, 12 and 24 months, and change in cartilage volume at 24 months. Secondary outcomes included WOMAC function, quality of life, analgesic and non-steroidal anti-inflammatory drug use and bone marrow lesion score.

RESULTS:

Although there was improvement in both groups, the low-dose fish oil group had greater improvement in WOMAC pain and function scores at 2 years compared with the high-dose group, whereas between-group differences at 1 year did not reach statistical significance. There was no difference between the two groups in cartilage volume loss at 2 years. For other secondary endpoints, there was no difference between the two groups at 2 years.

CONCLUSIONS:

In people with symptomatic knee OA, there was no additional benefit of a high-dose fish oil compared with low-dose fish oil. The combination comparator oil appeared to have better efficacy in reducing pain at 2 years, suggesting that this requires further investigation.

TRIAL REGISTRATION NUMBER:

Australian New Zealand Clinical Trials Registry (ACTRN 12607000415404).

KEYWORDS:

Epidemiology; Knee Osteoarthritis; Treatment

PMID:
26353789
DOI:
10.1136/annrheumdis-2014-207169
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center