Format

Send to

Choose Destination
Nat Neurosci. 2015 Nov;18(11):1559-61. doi: 10.1038/nn.4117. Epub 2015 Sep 9.

Persistence of Aβ seeds in APP null mouse brain.

Author information

1
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
2
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Tübingen, Germany.
3
Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany.
4
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia, USA.

Abstract

Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App(-/-) (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following secondary transmission. Thus, Aβ seeds can persist in the brain for months, and they regain propagative and pathogenic activity in the presence of host Aβ.

PMID:
26352792
DOI:
10.1038/nn.4117
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center