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J Dent Res. 2015 Nov;94(11):1495-501. doi: 10.1177/0022034515603972. Epub 2015 Sep 8.

Stem Cells in Teeth and Craniofacial Bones.

Author information

1
Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.
2
Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA huzhao@usc.edu ychai@usc.edu.

Abstract

Stem cells are remarkable, and stem cell-based tissue engineering is an emerging field of biomedical science aiming to restore damaged tissue or organs. In dentistry and reconstructive facial surgery, it is of great interest to restore lost teeth or craniofacial bone defects using stem cell-mediated therapy. In the craniofacial region, various stem cell populations have been identified with regeneration potential. In this review, we provide an overview of the current knowledge concerning the various types of tooth- and craniofacial bone-related stem cells and discuss their in vivo identities and regulating mechanisms.

KEYWORDS:

Gli1 protein; hedgehogs; mesenchymal stromal cells; neural crest; skull; stem cell niche

PMID:
26350960
PMCID:
PMC4622324
DOI:
10.1177/0022034515603972
[Indexed for MEDLINE]
Free PMC Article

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