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Hum Brain Mapp. 2015 Dec;36(12):5018-37. doi: 10.1002/hbm.22987. Epub 2015 Sep 9.

Neurofunctional topography of the human hippocampus.

Author information

1
Department of Psychology, Auburn University, 226 Thach Hall, Auburn, Alabama.
2
Department of Electrical and Computer Engineering, Auburn University, Auburn University Magnetic Resonance Imaging Research Center, 560 Devall Drive, Auburn, Alabama.
3
Department of Kinesiology, Auburn University, 226 Thach Hall, Auburn, Alabama.
4
Yale University School of Medicine, New Haven, Connecticut.
5
Siemens Healthcare, MR Research & Development, 51 Valley Stream Parkway, Malvern, Pennsylvania.
6
Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
7
Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.
8
Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
9
South Texas Veterans Health Care System, Research Service, 7400 Merton Minter, San Antonio, Texas.
10
Shenzhen University School of Medicine, Neuroimaging Laboratory, Nanhai Ave 3688, Shenzhen, Guangong, 518060, People's Republic of China.

Abstract

Much of what was assumed about the functional topography of the hippocampus was derived from a single case study over half a century ago. Given advances in the imaging sciences, a new era of discovery is underway, with potential to transform the understanding of healthy processing as well as the ability to treat disorders. Coactivation-based parcellation, a meta-analytic approach, and ultra-high field, high-resolution functional and structural neuroimaging to characterize the neurofunctional topography of the hippocampus was employed. Data revealed strong support for an evolutionarily preserved topography along the long-axis. Specifically, the left hippocampus was segmented into three distinct clusters: an emotional processing cluster supported by structural and functional connectivity to the amygdala and parahippocampal gyrus, a cognitive operations cluster, with functional connectivity to the anterior cingulate and inferior frontal gyrus, and a posterior perceptual cluster with distinct structural connectivity patterns to the occipital lobe coupled with functional connectivity to the precuneus and angular gyrus. The right hippocampal segmentation was more ambiguous, with plausible 2- and 5-cluster solutions. Segmentations shared connectivity with brain regions known to support the correlated processes. This represented the first neurofunctional topographic model of the hippocampus using a robust, bias-free, multimodal approach.

KEYWORDS:

7T; DTI; fMRI; high field; meta-analysis

PMID:
26350954
PMCID:
PMC4715517
DOI:
10.1002/hbm.22987
[Indexed for MEDLINE]
Free PMC Article

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