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Clin Neurophysiol. 2016 Feb;127(2):1629-38. doi: 10.1016/j.clinph.2015.08.006. Epub 2015 Aug 28.

Heart rate variability and serum level of insulin-like growth factor-1 are correlated with symptoms of emotional disorders in patients suffering a mild traumatic brain injury.

Author information

1
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
2
Graduate Program on Neuroregeneration, Taipei Medical University, Taipei 110, Taiwan.
3
Graduate Program on Neuroregeneration, Taipei Medical University, Taipei 110, Taiwan; Department of Neurosurgery, Taipei Medical University Hospital, Taipei 110, Taiwan.
4
Graduate Institute of Injury and Prevention, College of Public Health, Taipei Medical University, Taipei 110, Taiwan.
5
Department of Emergency, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.
6
Department of Psychiatry, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.
7
Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.
8
Department of Nuclear Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.
9
Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
10
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
11
Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
12
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. Electronic address: jywang2010@tmu.edu.tw.

Abstract

OBJECTIVE:

Patients who have experienced a mild traumatic brain injury (mTBI) are susceptible to symptoms of anxiety or depression. To explore the potential biomarkers for emotional disorders in mTBI patients, we analyzed the frequency domain of heart rate variability (HRV) and serum concentrations of four neurohormones.

METHODS:

We assessed mTBI patients on their first visit and follow-up. Symptoms were evaluated by the Beck Anxiety Inventory and the Beck Depression Inventory, respectively. Serum levels of adrenocorticotropic hormone (ACTH), melatonin, cortisol, and insulin-like growth factor (IGF)-1 and HRV follow-ups were measured and compared.

RESULTS:

mTBI patients were more vulnerable to symptoms of anxiety or depression than healthy controls. Reduced HRV was noted in mTBI patients compared to healthy controls. The mTBI patients demonstrated higher serum levels of ACTH, lower IGF-1 compared to healthy controls. In correlation analysis, only IGF-1 was positively correlated with HRV in mTBI patients. Both HRV and IGF-1 were correlated with symptom of depression while only HRV was correlated with symptom of anxiety in mTBI patients.

CONCLUSIONS:

We infer that HRV may be more significantly correlated with emotional disorders than is IGF-1 in mTBI patients.

SIGNIFICANCE:

The study is relevant for specific diagnostic markers in mTBI patients.

KEYWORDS:

Autonomic nervous system (ANS); Emotional disorder; Heart rate variability (HRV); Insulin-like growth factor-1 (IGF-1); Mild traumatic brain injury (mTBI)

PMID:
26350409
DOI:
10.1016/j.clinph.2015.08.006
[Indexed for MEDLINE]
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