Format

Send to

Choose Destination
Eur Neuropsychopharmacol. 2015 Nov;25(11):2008-14. doi: 10.1016/j.euroneuro.2015.08.015. Epub 2015 Aug 24.

Decreased expression of nociceptin/orphanin FQ in the dorsal anterior cingulate cortex of suicides.

Author information

1
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3.
2
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3; Department of Psychiatry, McGill University, Canada.
3
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3; Department of Psychiatry, McGill University, Canada. Electronic address: gustavo.turecki@mcgill.ca.

Abstract

The nociceptin/orphanin FQ (N/OFQ)-Nociceptin Opiod-like Peptide (NOP) receptor system is a critical mediator of physiological and pathological processes involved in emotional regulation and drug addiction. As such, this system may be an important biological substrate underlying psychiatric conditions that contribute to the risk of suicide. Thus, the goal of the present study was to characterize changes in human N/OFQ and NOP signaling as a function of depression, addiction and suicide. We quantified the expression of N/OFQ and NOP by RT-PCR in the anterior insula, the mediodorsal thalamus, and the dorsal anterior cingulate cortex (dACC) from a large sample of individuals who died by suicide and matched psychiatrically-healthy controls. Suicides displayed an 18% decrease in the expression of N/OFQ in the dACC that was not accounted for by current depressive or substance use disorders at the time of death. Therefore, our results suggest that dysregulation of the N/OFQ-NOP system may contribute to the neurobiology of suicide, a hypothesis that warrants further exploration.

KEYWORDS:

Addiction; Anterior Cingulate Cortex; Depression; Nociceptin Opiod-like Peptide receptor; Nociceptin/Orphanin FQ; Suicide

PMID:
26349406
PMCID:
PMC4655195
DOI:
10.1016/j.euroneuro.2015.08.015
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center