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J Med Food. 2016 Jan;19(1):106-9. doi: 10.1089/jmf.2014.3404. Epub 2015 Sep 8.

Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization.

Author information

1
1 Department of Ophthalmology, University of Ulsan , Gangneung Asan Hospital, Gangneung, Gangwon-do, Korea.
2
2 Natural Product Research Center, Korea Institute of Science and Technology (KIST) , Gangneung, Gangwon-do, Korea.
3
3 Department of Biological Chemistry, University of Science and Technology , Daejeon, Korea.

Abstract

The purpose of this study was to evaluate the effect of ethanol extract of Diospyros kaki (EEDK) leaves on corneal neovascularization (CoNV) in rats. One week after the alkali burns in the corneas, the CoNV area coverage in the CoNV-positive control group, 100 mg/kg EEDK group, and 200 mg/kg EEDK group was 43.3% ± 5.5%, 337.7% ± 2.5%, and 27.2% ± 4.3%, respectively. The areas of CoNV in the EEDK-treated groups were significantly different from those of the CoNV group. EEDK significantly attenuated the upregulation of vascular endothelial growth factor, fibroblast growth factor, interleukin-6, and matrix metalloproteinase-2 (MMP-2) protein levels. Orally administrated D. kaki inhibited CoNV development in rats.

KEYWORDS:

Diospyros kaki; alkali burn; angiogenic factors; corneal neovascularization; eye diseases

PMID:
26348484
PMCID:
PMC4717495
DOI:
10.1089/jmf.2014.3404
[Indexed for MEDLINE]
Free PMC Article

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