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FEBS Lett. 2015 Oct 7;589(20 Pt B):3182-8. doi: 10.1016/j.febslet.2015.08.040. Epub 2015 Sep 5.

Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles.

Author information

1
Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University, Frankfurt am Main, Germany.
2
Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt am Main, Germany.
3
Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University, Frankfurt am Main, Germany. Electronic address: dimmeler@em.uni-frankfurt.de.

Abstract

By transporting regulatory RNAs like microRNAs, extracellular vesicles provide a novel layer of intercellular gene regulation. However, the underlying secretory pathways and the mechanisms of cargo selection are poorly understood. Rab GTPases are central coordinators of membrane trafficking with distinct members of this family being responsible for specific transport pathways. Here we identified a vesicular export mechanism for miR-143, induced by the shear stress responsive transcription factor KLF2, and demonstrate its dependency on Rab7a/Rab27b in endothelial cells.

KEYWORDS:

Endothelial cell; Exosome; Microvesicle; Rab protein; microRNA

PMID:
26348397
DOI:
10.1016/j.febslet.2015.08.040
[Indexed for MEDLINE]
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