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Front Physiol. 2015 Aug 19;6:225. doi: 10.3389/fphys.2015.00225. eCollection 2015.

Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity?

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Concept Systems, Inc. Ithaca, NY, USA ; Department of Sociology, Cornell University Ithaca, NY, USA.
Biologische Heilmittel Heel GmbH Baden-Baden, Germany.
Transcend Research Laboratory, Massachusetts General Hospital Boston, MA, USA.
Concept Systems, Inc. Ithaca, NY, USA.
International Academy of Bioregulatory Medicine Baden-Baden, Germany.
Division of Genomic Medicine, George Washington University Medical Center Washington, DC, USA.
St. Laurent Institute Vancouver, WA, USA.
Center for Integrative Medicine, University of Maryland School of Medicine Baltimore, MD, USA.


Bioregulatory systems medicine (BrSM) is a paradigm that aims to advance current medical practices. The basic scientific and clinical tenets of this approach embrace an interconnected picture of human health, supported largely by recent advances in systems biology and genomics, and focus on the implications of multi-scale interconnectivity for improving therapeutic approaches to disease. This article introduces the formal incorporation of these scientific and clinical elements into a cohesive theoretical model of the BrSM approach. The authors review this integrated body of knowledge and discuss how the emergent conceptual model offers the medical field a new avenue for extending the armamentarium of current treatment and healthcare, with the ultimate goal of improving population health.


autoregulation; bioregulatory systems medicine; genomics; inflammation; systems biology; systems medicine

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