Format

Send to

Choose Destination
Acta Neurol Scand. 2016 May;133(5):380-3. doi: 10.1111/ane.12479. Epub 2015 Sep 8.

Does pregnancy per se make epilepsy worse?

Author information

1
Departments of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Vic., Australia.
2
Department of Neurology, Royal Brisbane and Women's Hospital, University of Queensland, Brisbane, Qld, Australia.
3
Faculty of Medicine and Biomedical Science, University of Queensland, Brisbane, Qld, Australia.

Abstract

OBJECTIVE:

To determine whether being pregnant in its own right alters epileptic seizure control.

MATERIALS/METHODS:

Study of 148 pregnancies in women who took no antiepileptic drugs before pregnancy and in at least the earlier half of pregnancy, 69 taking none throughout pregnancy.

RESULTS:

More women (P < 0.01) had seizures of any type during pregnancy (45.9%) than in the prepregnancy year (34.5%), and also convulsive seizures (30.4% vs 12.3%). After excluding potential confounding factors, viz. late prepregnancy drug withdrawal, treatment resumption in pregnancy possibly preventing seizure recurrence, the figures became seizures of any type 56.6% during and 35.5% before pregnancy and convulsive seizures 39.4% during and 18.2% before pregnancy (both P < 0.01). There was a non-statistically significant greater tendency for seizure control to be lost during pregnancy in genetic generalized than in focal epilepsies (54.2% vs 35.5%).

CONCLUSIONS:

Irrespective of its effects on antiepileptic drug disposition, being pregnant per se seems to impair epileptic seizure control.

KEYWORDS:

antiepileptic drugs; epilepsy; pregnancy; seizure control

PMID:
26347117
DOI:
10.1111/ane.12479
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center