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Future Microbiol. 2015;10(9):1433-45. doi: 10.2217/fmb.15.66. Epub 2015 Sep 7.

Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.

Author information

1
Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.
2
Department of Medicine & Therapeutics, Institute of Digestive Disease & LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
3
Department of Clinical Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China.
4
State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
5
Division of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China.

Abstract

AIMS:

To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression.

MATERIALS & METHODS:

The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were intervened by these two probiotics and the antitumor effects were examined by comparing the tumor incidence and detecting the inflammatory and immune-related markers.

RESULTS & CONCLUSIONS:

C. butyricum and B. subtilis inhibited the proliferation of CRC cells, caused cell cycle arrest and promoted apoptosis. In vivo, these two probiotics inhibited the development of DMH-induced CRC. The molecular mechanism involved reduced inflammation and improved immune homeostasis. This work establishes a basis for the protective role of probiotics B. subtilis and C. butyricum in intestinal tumorigenesis.

KEYWORDS:

colorectal cancer; gut microbiota; immunity; inflammation

PMID:
26346930
DOI:
10.2217/fmb.15.66
[Indexed for MEDLINE]

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