Purpose: To evaluate long-term results of low-fluence photodynamic therapy (PDT) with verteporfin in the treatment of chronic central serous chorioretinopathy (CCSC).
Methods: Retrospective medical record review of 38 eyes (34 patients) who received low-fluence PDT for the treatment of CCSC. Visual acuity (VA), fundus biomicroscopy, fluorescein angiography (FA), indocyanine green angiography (ICG) and optical coherence tomography (OCT) were analyzed.
Results: Thirty-eight eyes (34 patients) with CCSC received low-fluence PDT. Mean follow-up after PDT was 43.97 months. Mean logMar best corrected VA (BCVA) improved significantly from 0.33 to 0.11 at the last follow-up which corresponds to a gain of 2.2 lines. At 3 months, complete resolution of central subretinal fluid was achieved on OCT after 1 PDT in 37 eyes and after 2 PDTs in 1 eye (retreated at 3 months after first PDT). One patient developed choroidal neovascularization (CNV) 4 years after his low-fluence PDT and received anti-vascular endothelial growth factor (VEGF) injections.
Conclusion: Low-fluence PDT with verteporfin for CCSC seems efficacious and safe in the long-term.
Keywords: Choriorétinite séreuse centrale chronique; Choroidal vascular hyperpermeability; Chronic central serous chorioretinopathy; Décollement séreux rétinien; Fluence réduite; Hyperperméabilité choroïdienne; Low-fluence; Macular neurosensory detachment; Photodynamic therapy; Photothérapie dynamique; Serous retinal detachment; Verteporfin; Vertéporfine.
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