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J Ethnopharmacol. 2015 Dec 4;175:30-8. doi: 10.1016/j.jep.2015.08.048. Epub 2015 Sep 4.

Inhalation of Cedrus atlantica essential oil alleviates pain behavior through activation of descending pain modulation pathways in a mouse model of postoperative pain.

Author information

  • 1Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina at Palhoça, Santa Catarina, Brazil; Postgraduate Program in Health Sciences, University of Southern Santa Catarina at Palhoça, Santa Catarina, Brazil. Electronic address: daniel.martins4@unisul.br.
  • 2Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina at Palhoça, Santa Catarina, Brazil; Postgraduate Program in Health Sciences, University of Southern Santa Catarina at Palhoça, Santa Catarina, Brazil.
  • 3Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina at Palhoça, Santa Catarina, Brazil.
  • 4Department of Morphological Sciences, Centre of Biological Sciences, University Federal of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
  • 5Department of Chemistry, University Federal of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
  • 6Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Centre of Biological Sciences, University Federal of Santa Catarina, Florianópolis, Santa Catarina, Brazil.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Cedrus atlantica essential oil (CaEO) presents analgesic and anti-inflammatory sedative properties. However, it remains unknown whether CaEO alleviates acute postoperative pain.

MATERIALS AND METHODS:

Here, we investigated the effect of CaEO on postoperative pain and its mechanisms related to the descending pain control in Swiss males mice induced by a plantar incision surgery (PIS) in the hindpaw.

RESULTS:

Inhalation of CaEO (5', 30' or 60') markedly reduced mechanical hypersensitivity. This effect was prevented by pre-treatment with naloxone or p-chlorophenylalanine methyl ester (PCPA, 100mg/kg, i.p.)-induced depletion of serotonin. In addition, p-alpha-methyl-para-tyrosin (AMPT, 100mg/kg, i.p.)-induced depletion of norepinephrine, intraperitoneal injection of the α2-adrenergic receptor antagonist yohimbine (0.15 mg/kg, i.p.) or haloperidol (1mg/kg, i.p.) an antagonist of dopaminergic (D1 and D2) receptors prevented the effect of CaEO on hypersensitivity.

CONCLUSIONS:

These findings suggest that CaEO alleviates postoperative pain by activating the descending pain modulation pathways on the opioidergic, serotonergic, noradrenergic (α2-adrenergic) and dopaminergic (dopamine D1 and D2 receptors) systems.

KEYWORDS:

Aromatherapy; Ethnopharmacology; Incisional Pain; Mice; Surgery

PMID:
26344850
DOI:
10.1016/j.jep.2015.08.048
[PubMed - indexed for MEDLINE]
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