A new avenue to the synthesis of GAG-mimicking polymers highly promoting neural differentiation of embryonic stem cells

Mengmeng Wang; Zhonglin Lyu; Gaojian Chen; Hongwei Wang; Yuqi Yuan; Kaiguo Ding; Qian Yu; Lin Yuan; Hong Chen

doi:10.1039/c5cc06944k

A new avenue to the synthesis of GAG-mimicking polymers highly promoting neural differentiation of embryonic stem cells

Chem Commun (Camb). 2015 Oct 28;51(84):15434-7. doi: 10.1039/c5cc06944k.

Authors

Mengmeng Wang¹, Zhonglin Lyu, Gaojian Chen, Hongwei Wang, Yuqi Yuan, Kaiguo Ding, Qian Yu, Lin Yuan, Hong Chen

Affiliation

¹ College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. yuanl@suda.edu.cn chenh@suda.edu.cn.

PMID: 26344781
DOI: 10.1039/c5cc06944k

Abstract

A new strategy for the fabrication of glycosaminoglycan (GAG) analogs was proposed by copolymerizing the sulfonated unit and the glyco unit, 'splitted' from the sulfated saccharide building blocks of GAGs. The synthetic polymers can promote cell proliferation and neural differentiation of embryonic stem cells with the effects even better than those of heparin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation / drug effects
Cell Line
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Embryonic Stem Cells / drug effects*
Glycosaminoglycans / chemistry*
Mice
Polymers / chemical synthesis
Polymers / chemistry
Polymers / pharmacology*
Structure-Activity Relationship

Substances

Glycosaminoglycans
Polymers