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Chem Commun (Camb). 2015 Oct 28;51(84):15434-7. doi: 10.1039/c5cc06944k.

A new avenue to the synthesis of GAG-mimicking polymers highly promoting neural differentiation of embryonic stem cells.

Author information

1
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. yuanl@suda.edu.cn chenh@suda.edu.cn.

Abstract

A new strategy for the fabrication of glycosaminoglycan (GAG) analogs was proposed by copolymerizing the sulfonated unit and the glyco unit, 'splitted' from the sulfated saccharide building blocks of GAGs. The synthetic polymers can promote cell proliferation and neural differentiation of embryonic stem cells with the effects even better than those of heparin.

PMID:
26344781
DOI:
10.1039/c5cc06944k
[Indexed for MEDLINE]

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