Format

Send to

Choose Destination
J Clin Lipidol. 2015 Sep-Oct;9(5 Suppl):S29-40. doi: 10.1016/j.jacl.2015.04.006. Epub 2015 May 1.

Secondary hypertriglyceridemia in children and adolescents.

Author information

1
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: piers-blackett@ouhsc.edu.
2
Department of Pediatrics, Pediatric Endocrinology and Diabetes, Cook Children's Medical Center, Fort Worth, TX, USA.
3
Department of Pediatrics, Scott & White Healthcare, Temple, TX, USA; Division of Cardiology, Department of Internal Medicine, Scott & White Healthcare, Temple, TX, USA.

Abstract

Secondary dyslipidemia with predominant hypertriglyceridemia may occur as a consequence of both common and rare causes. After accounting for obesity and associated insulin resistance, clinicians should carefully consider other contributing factors and conditions. Genetic background and causative factors prevail during gestation, infancy, and childhood and continue in adults. Elevations in triglyceride (TG) are associated with transfer of TG to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) resulting in lipolysis, HDL degradation, and formation of atherogenic LDL particles. Defining and treating the underlying cause is the first step toward restoring the lipids and lipoproteins to normal, especially in cases with severe hypertriglyceridemia, who are at risk for acute pancreatitis. Disorders involving the liver, kidney, endocrine, and immune systems and medications need to be considered. Rare diseases such as lipodystrophy and glycogen storage disease are particularly challenging, and there have been promising new developments. Treatment depends on the severity; prevention of acute pancreatitis being a priority in severe cases and lifestyle modification being a foundation for general management followed by targeting TG and predictors of coronary artery disease such as LDL cholesterol and non-HDL cholesterol, when they exceed cutpoints.

KEYWORDS:

Atherogenic; Causes; Genetic; Hypertriglyceridemia; Non–HDL cholesterol; Pancreatitis; Treatment

PMID:
26343210
DOI:
10.1016/j.jacl.2015.04.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center