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Neurology. 2015 Oct 6;85(14):1195-201. doi: 10.1212/WNL.0000000000001995. Epub 2015 Sep 4.

Prevalence of neurogenetic disorders in the North of England.

Author information

1
From the Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
2
From the Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. patrick.chinnery@ncl.ac.uk.

Abstract

OBJECTIVE:

Genetic disorders enter the differential diagnosis of common neurologic diseases, but their overall prevalence is not known. We set out to determine their minimum prevalence.

METHODS:

Meta-analysis of epidemiologic data gathered from the same geographic region in the North of England.

RESULTS:

Monogenic neurologic disorders affect at least 90.9/100,000 (95% confidence interval 87.6-94.3), or 1 in 1,100 of the population in Northern England.

CONCLUSION:

As a group, neurogenetic disorders are not rare. These findings have implications for clinical service delivery.

Comment in

PMID:
26341866
PMCID:
PMC4607600
DOI:
10.1212/WNL.0000000000001995
[Indexed for MEDLINE]
Free PMC Article

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