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J Hepatol. 2016 Jan;64(1):203-14. doi: 10.1016/j.jhep.2015.08.028. Epub 2015 Sep 1.

Hepatocellular carcinoma and lifestyles.

Author information

1
Hepatology, Department of Clinical Research, University of Berne, Berne, Switzerland; University Clinic of Visceral Surgery and Medicine, Inselspital Berne, Berne, Switzerland.
2
Department of Visceral & Transplantation Surgery, University Hospital Zürich, Zürich, Switzerland.
3
Hepatology, Department of Clinical Research, University of Berne, Berne, Switzerland; University Clinic of Visceral Surgery and Medicine, Inselspital Berne, Berne, Switzerland. Electronic address: jean-francois.dufour@insel.ch.

Abstract

The majority of hepatocellular carcinoma occurs over pre-existing chronic liver diseases that share cirrhosis as an endpoint. In the last decade, a strong association between lifestyle and hepatocellular carcinoma has become evident. Abundance of energy-rich food and sedentary lifestyles have caused metabolic conditions such as obesity and diabetes mellitus to become global epidemics. Obesity and diabetes mellitus are both tightly linked to non-alcoholic fatty liver disease and also increase hepatocellular carcinoma risk independent of cirrhosis. Emerging data suggest that physical activity not only counteracts obesity, diabetes mellitus and non-alcoholic fatty liver disease, but also reduces cancer risk. Physical activity exerts significant anticancer effects in the absence of metabolic disorders. Here, we present a systematic review on lifestyles and hepatocellular carcinoma.

KEYWORDS:

AMPK; Diabetes; Exercise; Insulin; Liver cancer; Obesity; mTOR

PMID:
26341826
DOI:
10.1016/j.jhep.2015.08.028
[Indexed for MEDLINE]

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